DNA Topoisomerase IV

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.

Also Known As:

Topoisomerase IV; Topo IV; Topoisomerase IV Subunit A; Topoisomerase IV Subunit B; parC Gene Product; parC Gene Product, Topo IV; parE Gene Product; parE Gene Product, Topo IV; Topoisomerase IV, DNA; parC Protein; parE Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - DNA Topoisomerases: 100
      - Type II DNA Topoisomerases: 1640
        DNA Topoisomerase IV: 49
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Bacterial Proteins: 394
    - DNA Topoisomerase IV: 49

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Disease

Drug/Important Bio-Agent (IBA)